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HelpTest ID: TPSF Protein, Total, Spinal Fluid
Reporting Name
Protein, Total, CSFUseful For
Detecting disruptions of the blood-brain barrier or intrathecal synthesis of immunoglobulins
Specimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge specimen to remove any cellular material.
Specimen Minimum Volume
0.25 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 72 hours | |
| Frozen | 180 days |
Reference Values
≥12 months: 0-35 mg/dL
Reference values have not been established for patients that are <12 months of age.
Day(s) Performed
Monday through Sunday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
84157
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TPSF | Protein, Total, CSF | 2880-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TPSF | Protein, Total, CSF | 2880-3 |
Clinical Information
Cerebrospinal fluid (CSF) proteins are those that remain in CSF following the ultrafiltration of plasma through the choroidal capillary wall. Some proteins that are unique to CSF are synthesized in the central nervous system. In general, diseases that interrupt the integrity of the capillary endothelial barrier lead to an increase in the total CSF protein.
CSF protein is generally increased in all types of meningitis, cerebral infarction, brain abscess, meningovascular syphilis, subarachnoid hemorrhage, some brain tumors, trauma to the brain, some cases of multiple sclerosis, encephalomyelitis, and degenerative neurologic diseases. A decreased CSF protein may occur in water intoxication, CSF leak (CSF rhinorrhea or otorrhea), and hyperthyroidism.
Interpretation
Striking elevations of cerebrospinal fluid (CSF) total protein are noted in bacterial meningitis; smaller elevations occur in the other inflammatory diseases and with tumor or hemorrhage. The effect of any of these conditions is that the proportions of specific proteins in CSF increasingly resemble serum.
In order to assess increased permeability or increased intrathecal production of proteins, simultaneous serum specimen and CSF specimens should be taken.
Clinical Reference
1. Tietz Textbook of Clinical Chemistry. Fourth edition. Edited by CA Burtis, ER Ashwood, DE Bruns. Philadelphia, WB Saunders Company, 2006
2. Killingsworth LM: Clinical applications of protein determinations in biological fluids other than blood. Clin Chem 1982;28:1093-1103
3. Henry’s Clinical Diagnosis and Management by Laboratory Methods. Cerebrospinal, synovial, and serous body fluids. Edited by McPherson and Pincus. Philadelphia, WB Saunders Co, 2007, 431-435
Report Available
Same day/1 to 2 daysMethod Name
Reflectance Spectrophotometry
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.
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