Home
HelpTest ID: HEXU Iohexol, Timed Collection, Urine
Reporting Name
Iohexol, UUseful For
Determining glomerular filtration rate in urine specimens
Specimen Type
UrineSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions: Collect a timed urine specimen. Timing may be variable and patient dependent.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 35 days | ||
| Ambient | 7 days |
Reference Values
Not applicable
Day(s) Performed
Monday through Friday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HEXU | Iohexol, U | 93973-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 61712 | Iohexol, U | 93973-6 |
Clinical Information
The assessment of glomerular filtration rate (GFR) is an important parameter of kidney function utilized by clinicians in the care of patients with varying kidney diseases, and for clinical research when precise assessment of kidney function is necessary. The GFR is the sum of all the filtration rates of the individual nephrons within the kidney and, as such, reflects the number of functioning nephrons.
Urine concentrations of iohexol can be used for measurement of GFR following a subcutaneous injection of iohexol (plasma disappearance), or during a continuous infusion of iohexol when used in conjunction with plasma iohexol determinations (HEXP / Iohexol, Plasma). The results can be used to determine the clearance of iohexol, which is a measure of GFR.
Clinical Reference
1. Brown SC, O'Reilly PH. Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard. J Urol. 1991;146(3):675-679
2. Gaspari F, Perico N, Ruggenenti P, et al. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol. 1995;6(2):257-263
3. Schwartz GJ, Abraham AG, Furth SL, Warady BA, Munoz A. Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney disease. Kidney Int. 2010;77(1):65-71
4. Schmit DJ, Carroll LJ, Eckfeldt JH, Seegmiller JC. Verification of separate measurement procedures where analytical determinations influence the clinical interpretation of GFR: Iohexol quantitation by HPLC and LC-MS/MS. Clin Biochem. 2019;67:16-23
5. Seegmiller JC, Burns BE, Schinstock CA, Lieske JC, Larson TS. Discordance between iothalamate and iohexol urinary clearances. Am J Kid Dis. 2016;67(1):49-55
Report Available
3 to 4 daysMethod Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.
mcl-kidney